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Clinical testing of monotherapy is likely to be confounded by other coexisting deficiencies

10.1016/j.cell.2011.03.054 205 MacintyreA

Bailey CP, Wang R, Figueroa M, Zhang S, Wang L, Chandra J

the ATP generated by OXPHOS serves as the energy foundation for maintaining tight junction proteins of the bloodbrain barrier (such as Claudin-5, Occludin, and ZO-1) and efflux transport systems (such as P-glycoprotein)